--- Watanabe Yosuke --- Heavy flavor measurements with ALICE --- The ALICE detector at the LHC has been optimized for the studies of Quark-Gluon Plasma (QGP) created in heavy-ion collisions. Heavy quarks (charm and bottom) are one of the probes that has been extensively used to elucidate the properties of the QGP. They are dominantly produced at the initial stage of the collisions and experience the whole evolution of the system. In ALICE, heavy-quark production is studied by detecting electrons or muons from semi-leptonic decays of charm and bottom hadrons or by fully reconstructing hadronic decays of charm mesons and baryons. The measurements in pp collisions provide critical tests of predictions from QCD and also an essential baseline for the studies in heavy-ion collisions. The measurements in p-Pb collisions are useful to study cold nuclear matter effects. The multiplicity dependence studies set further constraints on the production and hadronization mechanisms and might signal the formation of the QGP in such small systems. Finally, the measurements in Pb-Pb collisions shed light on the interactions between heavy quarks and the QGP and also on the properties of the QGP itself. In this talk, we will present recent open heavy-flavor results from pp collisions, p-Pb collisions and Pb-Pb collisions, collected with the ALICE detector during the LHC Run-1 and Run-2. ---